Key result
Ageing in male mice was associated with decreased bone mineral density and significant up-regulation of renin, angiotensinogen, and angiotensin II expression in bone tissue.
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May implicate local bone RAS in age-related bone loss in mice; leaves open translation to human osteoporosis.
The local tissue-specific renin-angiotensin system (RAS) was identified. The aim of this study was to investigate the role of local bone RAS in the osteoporosis of aging mice. Twelve-month-old and two-month-old male mice were respectively assigned to the ageing and young groups. The tibias and femurs were collected for an analysis of histomorphology, bone mass, and gene and protein expression. H&E staining and micro-CT measurement showed a loss of the trabecular bone network and decrease of bone mineral density in the proximal tibial metaphysis of the aged mice. The PCR results indicated the significant up-regulation of renin and angiotensinogen (AGT) mRNA expression in both the tibia and femur of the ageing mice. Western blotting data showed that the tibial angiotensin II protein expression was significantly increased in the ageing group. The enhancement of renin and AGT expression in the bone tissue resulted in the increased production of angiotensin II which plays an important role in the pathology of age-related osteoporosis.
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Gu et al. (2012) studied Age-related osteoporosis. Ageing (12-month-old) vs. Young (2-month-old) was evaluated on Bone mass, histomorphology, and gene/protein expression of RAS components. Ageing in male mice was associated with decreased bone mineral density and significant up-regulation of renin, angiotensinogen, and angiotensin II expression in bone tissue.
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