Key result
A single dose of oil-adjuvanted cell culture adapted classical swine fever vaccine safely elicited high neutralizing antibody titers (91.23% inhibition at 30 days) that persisted up to 180 days.
Why the study?
Classical swine fever is a contagious, economically devastating disease in pigs, and the study aimed to evaluate immunity and duration of immune response for a cell culture CSF vaccine with and without adjuvant.
Does an adjuvanted cell culture adapted CSFV vaccine improve and prolong the immune response compared to non-adjuvanted vaccine or no vaccine in pigs?
Does an adjuvanted cell culture adapted CSFV vaccine improve and prolong the immune response compared to non-adjuvanted vaccine or no vaccine in pigs?
A single dose of oil-adjuvanted cell culture adapted CSFV vaccine provides early and sustained protective immunity in pigs up to 180 days, offering a practical alternative to booster vaccination.
May support single-dose regimens in swine; leaves open field efficacy and broader translation.
Background: Classical swine fever is a highly contagious economically devastating viral disease of pigs. In endemic country like India including NE States, vaccination is the best way for prevention and control. Although live attenuated vaccines are available, booster vaccination gives better protective immunity. Present study was designed to evaluate immunity and duration of immune response in cell culture CSF vaccine with and without incorporation of adjuvant. Methods: In the present study, four groups of CSFV free pigs containing 6 pigs in each group were immunized as follows- with cell culture adapted whole CSFV vaccine, adjuvanted with montanide oil, primary CSFV vaccine with booster and without booster and control group as unvaccinated. Immune response was demonstrated by per cent inhibition in blocking ELISA. Result: Vaccinated pigs elicited early antibody by 7th dpv which reached a peak at 30th dpv and maintaining high antibody titre upto 180dpv. Single oil adjuvanted whole vaccine effectively stimulated neutralizing antibody with 90-95% inhibition titre. In primary and booster vaccinated pigs, antibody titres showed significant difference. Oil adjuvanted vaccine was safe eliciting high neutralizing antibody titre with single vaccination till marketable age. Also a good comparison of all the four combinations of vaccines were obtained.
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Suokhrie et al. (2024) studied Classical Swine Fever (n=24). Cell culture adapted whole CSFV vaccine adjuvanted with montanide oil vs. Unvaccinated control and non-adjuvanted vaccine was evaluated on Humoral immune response (per cent inhibition in blocking ELISA) at 30 days post-vaccination (p=<0.01). A single dose of oil-adjuvanted cell culture adapted classical swine fever vaccine safely elicited high neutralizing antibody titers (91.23% inhibition at 30 days) that persisted up to 180 days.
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