Key result
In the isolated guinea-pig small intestine, compliance to fluid distension is mediated by a nitric oxide-dependent inhibitory neural reflex that is reduced by tetrodotoxin and L-NAME.
Population
Isolated guinea-pig small intestine
Comparison
Infusion of fluid at varying rates with… vs Control preparations
Design
Preclinical
Authors
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Does not inform clinical practice; leaves open translation of nitric oxide reflexes to human intestinal or cardiovascular motility.
The guinea-pig small intestine exhibits accommodation to infused fluid through a neurally mediated relaxation of the circular muscle involving nitric oxide.
Waterman et al. (1994) studied Isolated guinea-pig small intestine. Tetrodotoxin, papaverine, and transmitter antagonists (L-NAME, apamin, hyoscine, hexamethonium) vs. Control preparations was evaluated on Compliance (change in volume of infused fluid divided by intraluminal pressure change). In the isolated guinea-pig small intestine, compliance to fluid distension is mediated by a nitric oxide-dependent inhibitory neural reflex that is reduced by tetrodotoxin and L-NAME.