February 1, 1999The Journal of Biochemistry

Identification of Trimeric Myosin Phosphatase (PP1M) as a Target for a Novel PKC-Potentiated Protein Phosphatase-1 Inhibitory Protein (CPI17) in Porcine Aorta Smooth Muscle

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Population

Porcine aorta media (myofibrillar extract)

Design

Preclinical

Authors

SSShingo SenbaHokkaido University MEMasumi EtoOkayama University of Science MYMichio YazawaHokkaido University of Science

Discussion

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Implication

Provides mechanistic insight into animal smooth muscle regulation; leaves open translation to human vascular disorders.

Structured PICO

Population

Porcine aorta media (myofibrillar extract)

Intervention

CPI17 (phosphorylation-dependent inhibitory protein of protein phosphatase-1)

Outcome

Identification of the physiological target of CPI17 and kinetic analysis of its inhibitionsurrogate

Trimeric myosin phosphatase (PP1M) is identified as a physiological target of CPI17 in vascular smooth muscle, elucidating a mechanism for protein kinase C-mediated signal transduction.

Cite This Study

Senba et al. (1999) studied this question.

synapsesocial.com/papers/6a9c5e506a0b47dac776dbab https://doi.org/10.1093/oxfordjournals.jbchem.a022294

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Identification of Trimeric Myosin Phosphatase (PP1M) as a Target for a Novel PKC-Potentiated Protein Phosphatase-1 Inhibitory Protein (CPI17) in Porcine Aorta Smooth Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of Trimeric Myosin Phosphatase (PP1M) as a Target for a Novel PKC-Potentiated Protein Phosphatase-1 Inhibitory Protein (CPI17) in Porcine Aorta Smooth Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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