Key result
Mouse embryonic stem cell-derived PDGFRα+ cardiac lineage-committed cells were investigated for their regenerative potential in infarcted myocardium, but results are not reported in the truncated abstract.
Why the study?
Pluripotent stem cell-derived cardiomyocytes are attractive for cardiac cell therapy, leading investigators to examine the regenerative potential of proliferative, immature mouse embryonic stem cell-derived PDGFRα+ cardiac lineage-committed cells.
Investigation without reported outcomes leaves open regenerative potential of these cells in MI; further studies required before translation.
BACKGROUNDPluripotent stem cell-derived cardiomyocytes (CMs) have become one of the most attractive cellular resources for cell-based therapy to rescue damaged cardiac tissue. AIMWe investigated the regenerative potential of mouse embryonic stem cell (ESC)derived platelet-derived growth factor receptor-α (DGFRα) + cardiac lineagecommitted cells (CLCs), which have a proliferative capacity but are in a morphologically and functionally immature state compared with differentiated CMs. METHODS
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Hong et al. (2019) studied Infarcted myocardium. Mouse embryonic stem cell-derived PDGFRα+ cardiac lineage committed cells was evaluated. Mouse embryonic stem cell-derived PDGFRα+ cardiac lineage-committed cells were investigated for their regenerative potential in infarcted myocardium, but results are not reported in the truncated abstract.
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