Key result
Serum HMGB1 levels were significantly elevated in patients with coronary artery disease compared to healthy volunteers (63.5 vs 21.98 µg/l) and positively correlated with hs-CRP and cTnI levels.
Why the study?
Do serum HMGB1 levels correlate with hs-CRP and cardiac troponin I in patients with coronary artery disease?
Observational (n=128)
No
Do serum HMGB1 levels correlate with hs-CRP and cardiac troponin I in patients with coronary artery disease?
Absolute Event Rate: 63.5% vs 21.98%
p-value: p=<0.01
Serum HMGB1 levels are elevated in patients with coronary artery disease, particularly acute myocardial infarction, and correlate positively with hs-CRP and cardiac troponin I, suggesting its potential as a biomarker for disease severity.
The aim of this study was to evaluate the correlation between levels of serum high-mobility group box-1 (HMGB1) and high-sensitivity C-reactive protein (hs-CRP) and cardiac troponin I in patients with coronary artery disease. The levels of serum HMGB1, hs-CRP and cardiac troponin I were measured in 98 patients with coronary artery disease and in 30 healthy subjects. The correlation between serum HMGB1 levels and hs-CRP and cardiac troponin I levels was analyzed. Serum HMGB1 levels in patients with coronary artery disease were higher compared with those in healthy volunteers (63.5±15.29 vs. 21.98±4.33 µg/l; P<0.01). Serum HMGB1 levels in patients with acute myocardial infarction were higher compared with those in patients with unstable and stable angina pectoris (77.53±6.86 vs. 63.67±8.6 and 44.39±9.01 µg/l, respectively; both P<0.01). The levels of HMGB1 were positively correlated with hs-CRP and cardiac troponin I levels (r=0.657 and 0.554, respectively; both P<0.01) in patients with coronary artery disease. In conclusion, serum HMGB1 levels were elevated in patients with coronary artery disease, particularly in those with acute myocardial infarction. The levels of HMGB1 were correlated with the levels of hs-CRP and cardiac troponin I.
No takes yet. Share an insight, caveat, or question.
Yao et al. (2013) conducted an observational in Coronary artery disease (n=128). Coronary artery disease vs. Healthy volunteers was evaluated on Serum HMGB1 levels (p=<0.01). Serum HMGB1 levels were significantly elevated in patients with coronary artery disease compared to healthy volunteers (63.5 vs 21.98 µg/l) and positively correlated with hs-CRP and cTnI levels.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: