Key result
Elevated homocysteine is linked to ~2.3-fold higher coronary heart disease risk.
Why the study?
Although elevated serum homocysteine (Hcy) and high-sensitivity C-Reactive Protein (hs-CRP) are linked to endothelial damage and thrombus formation in coronary heart disease (CHD), their clinical utility remains debated due to inconsistencies in prior studies.
Are elevated serum homocysteine (>15 µmol/L) and high-sensitivity C-reactive protein (≥1 mg/L) levels associated with an increased prevalence of angiographically confirmed coronary heart disease in patients presenting with typical angina and dyslipidemia?
Cross-Sectional (n=72)
No
Are elevated serum homocysteine (>15 µmol/L) and high-sensitivity C-reactive protein (≥1 mg/L) levels associated with an increased prevalence of angiographically confirmed coronary heart disease in patients presenting with typical angina and dyslipidemia?
Answers are grounded in this paper and cite their sources.
Elevated serum homocysteine and hs-CRP levels are significantly associated with angiographically confirmed coronary heart disease, supporting their potential utility as complementary risk-enhancing biomarkers in cardiovascular risk stratification.
Coronary heart disease (CHD) is a major contributor to both morbidity and mortality. Elevated serum levels of homocysteine (Hcy) and high-sensitivity C-Reactive Protein (hs-CRP) are linked to endothelial damage and thrombus formation, contributing to CHD. Their clinical utility remains debated due to inconsistencies in prior studies despite being proposed as potential risk factors. This research was designed to assess how serum Hcy and CRP levels relate to the risk of CHD. A cross-sectional study was conducted on 72 subjects undergoing coronary angiography at our hospital. Serum Hcy levels were assessed by ELISA, and hs-CRP levels were assessed using a high-sensitivity latex-based immunoassay. The correlation between elevated Hcy and hs-CRP levels and CHD was evaluated using bivariate analysis and prevalence ratios (PR) with 95% confidence intervals (CI). Patients with CHD had significantly higher serum Hcy (14.51 ± 4.93 µmol/L) and hs-CRP levels (4.94 ± 4.36 mg/L) compared to those without CHD (8.04 ± 4.59 µmol/L, 1.46 ± 1.29 mg/L; p < 0.01 for both). The prevalence ratio for elevated Hcy and CHD was 2.322 (95% CI: 1.53–3.52, p < 0.01), and for hs-CRP, it was 4.804 (95% CI: 1.66–13.92, p < 0.01). Elevated serum Hcy and hs-CRP levels are significantly associated with increased CHD risk. These biomarkers may be useful for early identification of individuals at higher risk for CHD. Further studies are needed to confirm these findings and explore the clinical use of Hcy and hs-CRP in CHD risk assessment.
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Melissa et al. (2026) conducted a cross-sectional in Suspected coronary heart disease (CHD) undergoing diagnostic invasive coronary angiography (n=72). Elevated serum homocysteine (>15 µmol/L) and high-sensitivity C-reactive protein (≥1 mg/L) vs. Normal serum homocysteine (≤15 µmol/L) and high-sensitivity C-reactive protein (<1 mg/L) was evaluated on Coronary heart disease (defined as ≥50% stenosis in at least one major coronary artery on invasive angiography) associated with elevated homocysteine (>15 µmol/L) (PR 2.322, 95% CI 1.53-3.52, p=<0.001). Elevated serum homocysteine and hs-CRP were associated with increased coronary heart disease risk.
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