Key result
Children with risk factors for coronary heart disease had significantly higher serum levels of hs-CRP compared to children without risk factors (3.33 vs. 0.92 mg/L, p < 0.01).
Why the study?
Are hs-CRP levels elevated in children with risk factors for coronary heart disease compared to those without?
Population
77 children, comprising 51 with risk factors for coronary heart disease and 26 without any risk factors.
Design
Cross-sectional
Authors
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hs-CRP elevation associates with pediatric CHD risk factors; hypothesis-generating and requires validation before practice change.
Case-Control (n=77)
Are hs-CRP levels elevated in children with risk factors for coronary heart disease compared to those without?
Absolute Event Rate: 3.33% vs 0.92%
p-value: p=< 0.01
Serum hs-CRP is significantly elevated in children with coronary heart disease risk factors and correlates with BMI, diastolic blood pressure, fibrinogen, and HDL cholesterol, suggesting its potential utility as a screening marker.
Güran et al. (2007) conducted a case-control in Risk factors for coronary heart disease (n=77). Presence of CHD risk factors vs. Children without any risk factors was evaluated on Serum levels of hs-CRP (mg/L) (p=< 0.01). Children with risk factors for coronary heart disease had significantly higher serum levels of hs-CRP compared to children without risk factors (3.33 vs. 0.92 mg/L, p < 0.01).
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