Key result
Cultured rat astrocytes possess a Na+-Ca2+ exchanger that operates in reverse mode, is modulated by external K+, and is confirmed by protein and mRNA expression.
Population
Cultured rat astrocytes
Comparison
Ouabain and monensin or lowered external Na+… vs Inhibitors or baseline conditions
Design
Preclinical
Authors
Loading...
No immediate implications for cardiovascular care; leaves open glial Na+-Ca2+ exchange roles pending human validation.
Cultured rat astrocytes possess a functional Na+-Ca2+ exchanger that is modulated by external K+.
Takuma et al. (1994) studied this question. Ouabain and monensin was evaluated on 45Ca2+ uptake and intracellular Ca2+ concentration. Cultured rat astrocytes possess a Na+-Ca2+ exchanger that operates in reverse mode, is modulated by external K+, and is confirmed by protein and mRNA expression.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: