Key result
Topical application of L-NMMA constricted the basilar artery by 11% and abolished the dilator response to acetylcholine, effects that were prevented by L-arginine.
Population
Anesthetized rats
Comparison
Topical application of NG-monomethyl-L-arginine… vs Control conditions
Design
Preclinical
Authors
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Does not inform human cerebrovascular therapy; extends in vivo evidence for L-arginine-derived NO in basilar artery regulation.
Nitric oxide synthesized from L-arginine plays a key role in maintaining resting tone and mediating acetylcholine-induced vasodilation in the basilar artery in vivo.
Frank M. Faraci (1990) studied this question. L-NMMA vs. Control conditions was evaluated on Diameter of the basilar artery. Topical application of L-NMMA constricted the basilar artery by 11% and abolished the dilator response to acetylcholine, effects that were prevented by L-arginine.
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