Key result
Pretreatment with adenovirus-mediated angiopoietin-1 significantly reduced the median percent necrotic area of skin flaps compared to control (11.01% vs 32.24%, P<0.001) in a rat model.
Why the study?
Does adenovirus-mediated angiopoietin-1 gene therapy improve skin flap survival in a rat epigastric skin flap model?
Population
Rats with an epigastric skin flap model
Comparison
Subdermal injections of adenovirus encoding… vs Subdermal injections of adenovirus encoding…
Design
Preclinical
Follow-up
7 days post-surgery
Authors
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Hypothesis-generating for angiopoietin-1 gene therapy in flap survival; leaves open translation to human microsurgery.
Does adenovirus-mediated angiopoietin-1 gene therapy improve skin flap survival in a rat epigastric skin flap model?
Absolute Event Rate: 11.01% vs 32.24%
p-value: p=< 0.001
Adenovirus-mediated angiopoietin-1 gene therapy significantly reduces skin flap necrosis in a rat model, suggesting potential utility for therapeutic angiogenesis in reconstructive procedures.
Jung et al. (2003) studied Skin flap survival (animal model). Adenovirus encoding angiopoietin-1 vs. Adenovirus encoding green fluorescent protein or no treatment was evaluated on Skin flap survival (percentage of necrotic area over total skin flap area) (p=< 0.001). Pretreatment with adenovirus-mediated angiopoietin-1 significantly reduced the median percent necrotic area of skin flaps compared to control (11.01% vs 32.24%, P<0.001) in a rat model.
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