Key result
Complementation of a highly purified 45-kDa brain-specific nuclear protein with HeLa extract significantly increased JCVE promoter activity in vitro.
Population
In vitro glial cells and HeLa cell extracts
Comparison
Purified 45-kDa brain-specific nuclear protein vs HeLa extract without the purified 45-kDa protein
Design
Preclinical
Authors
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May identify glial transcription factor for JCVE; hypothesis-generating, requires in vivo validation before any clinical consideration.
A novel 45-kDa glial-origin transcription factor binds to the JCVE promoter and can stimulate its transcription even in a non-glial context.
Ahmed et al. (1990) studied this question. 45-kDa nuclear protein from brain cells was evaluated on JCVE promoter activity. Complementation of a highly purified 45-kDa brain-specific nuclear protein with HeLa extract significantly increased JCVE promoter activity in vitro.
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