Key result
Moderate psychological stress in healthy young subjects was associated with coactivation of sympathetic-parasympathetic regulatory mechanisms and early signs of microcirculatory dysfunction.
Why the study?
Does the level of subjectively experienced emotional stress affect microcirculation and autonomic regulation in healthy young subjects?
Observational
Does the level of subjectively experienced emotional stress affect microcirculation and autonomic regulation in healthy young subjects?
Moderate everyday psychological stress in healthy young subjects is associated with early signs of endothelium-mediated microcirculatory dysfunction and altered autonomic regulation.
Answers are grounded in this paper and cite their sources.
No immediate clinical action in healthy youth; hypothesis-generating for stress-microcirculation links in prospective studies.
A comprehensive comparative analysis of hemodynamics, microcirculation (the method of laser Doppler flowmetry with an occlusion test and the optical tissue oxymetry), blood circulation neurohumoral regulation (analysis of heart rate variability, HRV) in apparently healthy young subjects with different levels of subjectively experienced emotional stress has been performed. Depending on the degree of everyday stress (acute and/or chronic), the character of the autonomic regulation of blood circulation, as well as the state of the microcirculation and its regulation substantially vary. Moderate stress is accompanied by coactivation of sympathetic-parasympathetic regulatory mechanisms with augmented HRV baroreflex regulation circuits, which compensates for hemodynamic changes and is not accompanied by hypotensive reactions. An increase in the activity of neurogenic and myogenic tones of microhemodynamics in the subjects with moderate stress, which determines a high probability of blood shunting in tested tissue and decrease in relative oxygen extraction, has been discovered. Moderate levels of stress are also associated with an increase in the latency of postocclusive vasoreactive hyperemia, which is considered to be an early sign of the endothelium-mediated dysfunction of microcirculation.
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Глазачев et al. (2012) conducted an observational in Psychological stress. Moderate psychological stress vs. Other levels of stress was evaluated on Hemodynamics, microcirculation, and blood circulation neurohumoral regulation. Moderate psychological stress in healthy young subjects was associated with coactivation of sympathetic-parasympathetic regulatory mechanisms and early signs of microcirculatory dysfunction.
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