Key result
Local heating of the Pallid bat wing increased the total number of perfused capillaries by 92.7% (P=0.011), a response that persisted despite NOS and sensorineural blockade.
Population
Pallid bat wing model (n=8 per experimental group)
Comparison
Local heating of a 3 cm2 portion of the wing… vs Baseline (25 degrees C) and/or without blockade
Design
Preclinical
Follow-up
20 min
Authors
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Demonstrates NOS-independent capillary recruitment by local heating in bats; hypothesis-generating for human thermoregulatory microcirculation.
p-value: p=0.011
Capillary recruitment is a fundamental microvascular response to local heat, independent of arteriolar dilation and NOS/sensorineural mechanisms.
Widmer et al. (2007) studied Healthy (animal model) (n=8). Local heating vs. Baseline (25 degrees C) was evaluated on Total number of perfused capillaries (p=0.011). Local heating of the Pallid bat wing increased the total number of perfused capillaries by 92.7% (P=0.011), a response that persisted despite NOS and sensorineural blockade.
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