Key result
Age >60 years (HR 3.054; 95% CI 1.597-5.842), hypoproteinemia, hyperglycemia, higher eGFR, and severe heart failure were independent predictors of 3-month mortality in urgent-start PD patients.
Why the study?
The study was conducted to assess risk factors for early death in patients undergoing urgent-start peritoneal dialysis.
Cohort (n=1,265)
Yes
Hazard Ratio: 3.054 (95% CI 1.597–5.842)
p-value: p=0.001
Severe heart failure, older age, hypoproteinemia, hyperglycemia, and higher eGFR are significant independent risk factors for early mortality within 3 months in patients initiating urgent-start peritoneal dialysis.
May guide risk stratification in urgent-start PD; leaves open whether targeting predictors improves survival.
BACKGROUND: Assess risk factors for early death in patients who underwent urgent-start peritoneal dialysis (USPD). METHODS: Patients who initiated USPD in five peritoneal dialysis centers from 2013 to 2019 were screened in this multicenter retrospective cohort study. Risk factors for all-cause mortality within 3 months were explored. RESULTS: A total of 1265 USPD patients with 43 early deaths were included. Cox regression analyses showed that age older than 60 years (hazard ratio [HR], 3.054; 95% CI [1.597, 5.842]; p = 0.001), albumin less than 30 g/L (HR, 2.234; 95%CI [1.207, 4.136]; p = 0.011), blood glucose greater than 7 mmol/L (HR, 2.766; 95%CI [1.477, 5.180]; p = 0.001), higher estimated glomerular filtration rate (eGFR; HR, 1.121; 95%CI [1.071, 1.172]; p = 0.000), and poor stages of heart failure (class IV compared with class 0-I; HR, 5.165; 95%CI [2.544, 10.486]; p = 0.000) were independent predicting factors for early death. CONCLUSIONS: Risk factors for early death were older age, hypoproteinemia, hyperglycemia, higher eGFR, and severe heart failure.
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Meng et al. (2021) conducted a cohort in Urgent-start peritoneal dialysis (n=1,265). Age > 60 years vs. Age ≤ 60 years was evaluated on All-cause mortality within 3 months (HR 3.054, 95% CI 1.597-5.842, p=0.001). Age >60 years (HR 3.054; 95% CI 1.597-5.842), hypoproteinemia, hyperglycemia, higher eGFR, and severe heart failure were independent predictors of 3-month mortality in urgent-start PD patients.
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