Key result
The yeast Arp2/3 complex significantly accelerates yeast actin polymerization in the absence of an activating factor, indicating yeast F-actin can serve as a primary yArp2/3-activating factor.
Yeast F-actin can serve as a primary yArp2/3-activating factor, indicating that newly formed yeast actin filaments have a unique topology recognized specifically by yArp2/3.
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F-actin may activate yArp2/3 without NPFs in yeast; leaves open relevance to mammalian cytoskeletal dynamics.
Wen et al. (2005) studied this question. Yeast Arp2/3 complex (yArp2/3) vs. Absence of yArp2/3 or presence/absence of Las17p WA was evaluated on Rate of actin polymerization. The yeast Arp2/3 complex significantly accelerates yeast actin polymerization in the absence of an activating factor, indicating yeast F-actin can serve as a primary yArp2/3-activating factor.
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