Key result
Arp2Delta Arp2/3 complex remains inactive in actin nucleation despite maintaining structure and monomer recruitment.
The Arp2 subunit is essential for actin nucleation by the Arp2/3 complex but not for structural integrity or VCA binding.
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Arp2 is required for Arp2/3 nucleation; leaves open its mechanistic role in cellular actin dynamics and disease models.
Nolen et al. (2008) studied this question. Arp2Delta Arp2/3 complex vs. Full Arp2/3 complex was evaluated on Actin nucleation activity. The Arp2Delta Arp2/3 complex lacking the Arp2 subunit was inactive in actin nucleation assays despite maintaining its overall structure and ability to recruit actin monomers via VCA.
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