Key result
Intensively treated IDDM subjects had significantly higher fasting muscle sympathetic nerve activity than conventionally treated subjects (16.2 vs 10.5 bursts/min, P<0.05).
Why the study?
Does intensive glycemic control increase muscle sympathetic nerve activity in patients with insulin-dependent diabetes mellitus compared to conventional treatment?
Population
16 subjects with insulin-dependent diabetes mellitus enrolled in the Diabetes Control and Complications Trial
Comparison
Intensive glycemic control treatment vs Conventional glycemic control treatment
Design
Cross-sectional
Authors
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Intensive glycemic control was associated with higher MSNA in IDDM; leaves open clinical relevance and requires prospective validation.
Observational (n=16)
Does intensive glycemic control increase muscle sympathetic nerve activity in patients with insulin-dependent diabetes mellitus compared to conventional treatment?
Absolute Event Rate: 16.2% vs 10.5%
p-value: p=< 0.05
Improved long-term glycemic control in insulin-dependent diabetes mellitus is associated with increased sympathetic neural outflow to muscle.
Hoffman et al. (1995) conducted an observational in Insulin-dependent diabetes mellitus (IDDM) (n=16). Intensive treatment vs. Conventional treatment was evaluated on Fasting muscle sympathetic nerve activity (MSNA) levels (bursts/min) (p=< 0.05). Intensively treated IDDM subjects had significantly higher fasting muscle sympathetic nerve activity than conventionally treated subjects (16.2 vs 10.5 bursts/min, P<0.05).
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