Key result
Lipopolysaccharide injection in adult rats induced rapid iNOS expression in neutrophils, endothelial cells, and hepatocytes, preceding expression in macrophages during endotoxic shock.
In experimental endotoxic shock, the expression of iNOS in neutrophils, endothelial cells, and hepatocytes precedes that of macrophages and is closely associated with disease progression.
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Early iNOS sources in endotoxemia warrant no clinical targeting yet; leaves open cell-specific roles in human septic shock progression.
Sato et al. (1995) studied Experimental endotoxic shock. Lipopolysaccharide (LPS) injection vs. Control rats was evaluated on Expression of iNOS in various organs and tissues. Lipopolysaccharide injection in adult rats induced rapid iNOS expression in neutrophils, endothelial cells, and hepatocytes, preceding expression in macrophages during endotoxic shock.
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