A convergent synthetic approach to the tetracyclic core framework of khayanolide-type limonoids

This is the authors' abstract. We don't add key points for this paper.

A convergent approach for the enantioselective construction of an advanced intermediate containing the [5,5,6,6]-tetracyclic core framework of the khayanolide-type limonoids was described. The strategy features an acylative kinetic resolution of the benzylic alcohol, a 1,2-Grignard addition and an AcOH-interrupted Nazarov cyclization.