Key result
Central augmentation index was significantly higher in patients with obstructive peripheral arterial disease compared to those with aneurysmatic disease (beta = 0.21, p=0.006).
Why the study?
Does central augmentation index (cAIx) differ between patients with obstructive peripheral arterial disease and those with aneurysmatic disease?
Cross-Sectional (n=184)
Open-label
No
Does central augmentation index (cAIx) differ between patients with obstructive peripheral arterial disease and those with aneurysmatic disease?
Effect estimate: beta = 0.21
Absolute Event Rate: 31.4% vs 27.3%
p-value: p=0.006
Central augmentation index (cAIx) is significantly higher in patients with obstructive peripheral arterial disease compared to those with aneurysmatic disease, suggesting it can differentiate between patterns of vascular disease.
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Supports distinct arterial stiffness in obstructive versus aneurysmatic PAD; hypothesis-generating and requires prospective validation before clinical use.
Beckmann et al. (2015) conducted a cross-sectional in Peripheral arterial disease and/or abdominal aortic aneurysm (n=184). Peripheral arterial disease (obstructive pattern) vs. Abdominal aortic aneurysm (aneurysmatic pattern) was evaluated on Central augmentation index (cAIx) (beta = 0.21, p=0.006). Central augmentation index was significantly higher in patients with obstructive peripheral arterial disease compared to those with aneurysmatic disease (beta = 0.21, p=0.006).
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