Key result
Midodrine administration in a hemodialysis patient resulted in vascular ischemia.
Case Report (n=1)
Midodrine, although widely used for hemodialysis-associated hypotension, can cause severe adverse effects such as vascular ischemia in patients with ESRD.
May signal ischemia risk with midodrine in hemodialysis; case report leaves open confirmation in larger cohorts.
Midodrine is an alpha-agonist that causes peripheral vasoconstriction, resulting in increased blood pressure. It has been reported to be safe and effective in patients with end stage renal disease (ESRD) and is widely used for hemodialysis-associated hypotension. We report a case report of midodrine-induced ischemia in a patient on hemodialysis and review the literature relating to the safety of midodrine in patients with end stage renal disease.
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Rubinstein et al. (2008) conducted a case report in End stage renal disease on hemodialysis (n=1). Midodrine was evaluated on Vascular ischemia. Midodrine administration in a hemodialysis patient resulted in vascular ischemia.