Neurovascular Complications Following Clavicle Fracture Fixation: Timing, Mechanisms, and Clinical Implications

This review addresses the neurovascular complications associated with the surgical treatment of clavicle fractures through open reduction and internal fixation (ORIF). Despite being a generally safe procedure, it can lead to severe complications including brachial plexopathy, pseudoaneurysm, arteriovenous fistulas (AVF), deep vein thrombosis (DVTs), and thoracic outlet syndrome (TOS). One significant observation, not often highlighted in previous literature, is that neurovascular complications are more common in cases involving delayed fixation, nonunion, or malunion, compared to those treated acutely. This review emphasizes the impact of the timing of surgery on the frequency of these rare complications and examines their underlying mechanisms.