Key result
Large doses of hormones resulted in the disappearance of significant murmurs twice as often as small doses in children with acute rheumatic carditis.
Why the study?
Do large doses of hormones improve the disappearance of significant murmurs in children with acute rheumatic carditis compared to small doses?
Cohort (n=88)
Do large doses of hormones improve the disappearance of significant murmurs in children with acute rheumatic carditis compared to small doses?
Large doses of hormones are more effective than small doses in eliminating significant murmurs in children with acute rheumatic carditis.
Answers are grounded in this paper and cite their sources.
Large-dose hormones were associated with more murmur resolution in rheumatic carditis; hypothesis-generating and should not change practice pending RCTs.
Disappearance of significant murmurs was twice as common in 47 rheumatic children treated with large doses of hormones as in a comparable group of 41 children treated with small doses of hormones. Results were also related to the duration of illness before therapy was started. The findings suggest that the divergencies of opinion regarding the efficacy of hormones in the treatment of acute rheumatic carditis may in part be explained on the basis of differences in doses of hormones, in duration of therapy, and in duration of illness before the beginning of therapy.
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Roy et al. (1956) conducted a cohort in Acute rheumatic carditis (n=88). Hormones vs. Small doses was evaluated on Disappearance of significant murmurs (Twice as common). Large doses of hormones resulted in the disappearance of significant murmurs twice as often as small doses in children with acute rheumatic carditis.
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