Key result
EWS-Ets fusion proteins cooperatively bind DNA with AP-1 proteins, and this interaction is required for target gene activation and cellular transformation in Ewing's sarcoma models.
Population
In vitro and cell culture models studying Ewing's sarcoma EWS-Ets fusion proteins
Comparison
EWS-Ets fusion proteins and AP-1 proteins vs Mutant forms or other Ets family members
Design
Preclinical
Authors
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Should not yet change Ewing sarcoma management; hypothesis-generating for AP-1 targeting in fusion-driven models.
Cooperative DNA binding between EWS-Ets fusion proteins and AP-1 is essential for their biological activity and the pathogenesis of Ewing's sarcoma.
Kim et al. (2006) studied Ewing's sarcoma. EWS-Ets Fusion Proteins vs. Mutant EWS-Fli1 lacking cooperative binding was evaluated on Cooperative DNA binding and cellular transformation. EWS-Ets fusion proteins cooperatively bind DNA with AP-1 proteins, and this interaction is required for target gene activation and cellular transformation in Ewing's sarcoma models.
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