Cardiotoxicity of Carfilzomib in Two Japanese Patients with Relapsed Multiple Myeloma

Figures

• 

  Figure 1.. The clinical course of Case 1. A 76-year-old man, who was treated with KRd therapy for 3 months, visited the emergency room of our hospital complaining of dyspnea and orthopnea. He was diagnosed with congestive heart failure and treatment for heart failure was initiated.

• 

  Figure 2.. The change in the echocardiography findings of Case 1. Representative M-mode echocardiographic images of Case 1. Echocardiography showed significant improvement in the cardiac function after the cessation of CFZ.

• 

  Figure 3.. The clinical course of Case 2. A 75-year-old woman, who was treated with KRd therapy due to relapsed MM, presented with symptoms related to heart failure at 5 months after the initiation of KRd therapy. As we considered the possibility that the patient’s cardiac manifestations were associated with CFZ, KRd therapy was discontinued with the intensification of diuretic treatment.

• 

  Figure 4.. Changes in the echocardiography findings in Case 2. Representative M-mode echocardiographic images of Case 2. Although the patient’s symptoms of heart failure disappeared within 10 days after cessation of CFZ treatment, the cardiac function, as measured by echocardiography, was not restored.