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The present communication deals with the development of a new, simple, specific, sensitive, rapid and economical procedure for simultaneous estimation of atorvastatin calcium and amlodipine besylate in a combined dosage form. The method is based on the native ultraviolet absorbance maxima of the two chemotherapeutic agents. As both compounds do not interact chemically in methanol, two wavelengths 246 nm for atorvastatin calcium and 360 nm for amlodipine besylate were used. Both the drugs obeyed Beer's law in the concentration range that was employed in the method.
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Mishra et al. (2007) studied this question.
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