Key result
Thrombomodulin is a specific and highly sensitive marker for angiosarcomas compared with FVIII-RAG or UEA-I, whereas UEA-I is more sensitive for benign vascular tumors.
Why the study?
Is thrombomodulin a more sensitive and specific marker for vascular tumors compared to Factor VIII and Ulex europaeus I lectin?
Population
Various vascular tumors and other mesenchymal tumors of nonvascular origin
Comparison
Immunoperoxidase staining for Thrombomodulin (TM) vs Staining for Factor VIII-related antigen and…
Authors
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Thrombomodulin may aid angiosarcoma diagnosis in select pathology cases; leaves open prospective validation before routine adoption.
Observational
Is thrombomodulin a more sensitive and specific marker for vascular tumors compared to Factor VIII and Ulex europaeus I lectin?
Thrombomodulin serves as a highly sensitive and specific immunohistochemical marker for diagnosing angiosarcomas.
Yonezawa et al. (1987) conducted an observational in Vascular tumors. Thrombomodulin (TM) staining vs. Factor VIII-related antigen (FVIII-RAG) and Ulex europaeus agglutinin-I (UEA-I) was evaluated on Sensitivity and specificity for vascular tumors. Thrombomodulin is a specific and highly sensitive marker for angiosarcomas compared with FVIII-RAG or UEA-I, whereas UEA-I is more sensitive for benign vascular tumors.
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