Key result
A systemic inflammatory index >336 predicted diabetic kidney injury with 75% sensitivity and 70% specificity, with median values significantly higher in the injury group (584 vs 282, p<0.001).
Why the study?
Diabetic nephropathy involves chronic inflammation, and the study aimed to evaluate the relationship between the systemic inflammatory index and diabetic nephropathy.
Does the Systemic Inflammatory Index predict diabetic kidney injury in patients with Type 2 Diabetes Mellitus?
Case-Control
Does the Systemic Inflammatory Index predict diabetic kidney injury in patients with Type 2 Diabetes Mellitus?
The Systemic Inflammatory Index is a readily available biomarker that may help identify diabetic kidney injury in patients with type 2 diabetes.
Answers are grounded in this paper and cite their sources.
SII may support detection of diabetic kidney injury in type 2 diabetes; hypothesis-generating and requires prospective validation before clinical adoption.
Background: The systemic inflammatory index (SII) is a new inflammatory marker that has been the subject of various studies in diseases with chronic inflammation. Diabetic nephropathy is also a disease that goes with chronic inflammation. We aimed to evaluate the relationship be-tween SII and diabetic nephropathy. Methods: Patients with diabetes who applied to our outpatient clinic are included in the study. Diabetic patients are divided into two groups: those with diabetic nephropathy and those with-out. In addition, healthy individuals who applied to our clinic for general check-ups during these dates are included as control group. The SII values and other characteristics of the three study groups are compared. Results: The median SII value for those with DKI was 584 (178-4819); for those without DKI, it was 282 (64-618); and for the control group, it was 236 (77.5-617) (p<0.001). SII was significantly and positively correlated with BMI, weight, blood glucose, HbA1c, CRP and creatinine, and neg-atively correlated with glomerular filtration rate (GFR) value. The SII value higher than 336 has 75% sensitivity and 70% specificity in detecting DKI. Conclusion: The SII value could predict diabetic kidney injury in diabetics and it could be used as an adjunctive diagnostic tool.
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Duman et al. (2023) conducted a case-control in Diabetic Kidney Injury in Type 2 Diabetes Mellitus. Systemic inflammatory index (SII) vs. Patients without diabetic kidney injury and healthy controls was evaluated on Systemic inflammatory index (SII) value (p=<0.001). A systemic inflammatory index >336 predicted diabetic kidney injury with 75% sensitivity and 70% specificity, with median values significantly higher in the injury group (584 vs 282, p<0.001).
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