Key result
Gene silencing of tbCPSF30 by RNA interference in Trypanosoma brucei caused accumulation of unprocessed tubulin RNAs, demonstrating its essential role in polycistronic RNA processing.
tbCPSF30 is an essential core component of the T. brucei cleavage and polyadenylation machinery involved in polycistronic RNA processing.
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tbCPSF30 may represent a novel antiparasitic target; leaves open whether inhibition can be translated to human African trypanosomiasis therapy.
Hendriks et al. (2003) studied Trypanosoma brucei. RNA interference targeting tbCPSF30 was evaluated on RNA processing and cell viability. Gene silencing of tbCPSF30 by RNA interference in Trypanosoma brucei caused accumulation of unprocessed tubulin RNAs, demonstrating its essential role in polycistronic RNA processing.
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