September 1, 2001Journal of Biological ChemistryOpen Access

TcUBP-1, a Developmentally Regulated U-rich RNA-binding Protein Involved in Selective mRNA Destabilization in Trypanosomes

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Structured PICO

Population

Trypanosoma cruzi (agent of Chagas disease)

Intervention

Over-expression of TcUBP-1

Outcome

Half-life of SMUG mucin mRNAs in vivosurrogate

TcUBP-1 is a novel RNA-binding protein in Trypanosoma cruzi that regulates protein expression during differentiation by selectively destabilizing specific mRNAs.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May guide parasite differentiation studies; leaves open any therapeutic relevance to Chagas disease.

Cite This Study

D’Orso et al. (2001) studied this question.

synapsesocial.com/papers/6a74173555a91aadd1391bf9 https://doi.org/10.1074/jbc.m102120200

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TcUBP-1, a Developmentally Regulated U-rich RNA-binding Protein Involved in Selective mRNA Destabilization in Trypanosomes

Structured PICO

Discussion

Implication

Cite This Study

TcUBP-1, a Developmentally Regulated U-rich RNA-binding Protein Involved in Selective mRNA Destabilization in Trypanosomes

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider