Key result
Newly identified TcRBP family in Trypanosoma cruzi interacts with specific transcripts in a stage-specific manner.
This study identifies a family of RNA-binding proteins in Trypanosoma cruzi that interact with specific transcripts in vivo, providing insight into post-transcriptional gene regulation in the parasite that causes Chagas' disease.
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No immediate clinical impact; leaves open whether TcRBPs can be exploited for Chagas therapies.
Gaudenzi et al. (2003) studied Chagas' disease (Trypanosoma cruzi infection). A family of RNA-binding proteins (TcRBP) in Trypanosoma cruzi was identified and shown to interact with specific transcripts in vivo in a stage-specific manner.
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