Key result
TcUBP1 overexpression in Trypanosoma cruzi up-regulates surface protein transcripts >10-fold and increases polysome abundance.
Why the study?
The study was conducted to characterize an RNA regulon comprising numerous transcripts of trypomastigote-associated cell-surface glycoproteins preferentially expressed in infective stages of Trypanosoma cruzi.
Effect estimate: >10 times up-regulated
TcUBP1 up-regulates an RNA regulon for cell surface-associated glycoproteins in Trypanosoma cruzi, which is associated with the infective stages of the parasite.
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No immediate clinical implications for Chagas disease; leaves open whether TcUBP1 targeting could affect parasite infectivity.
Sabalette et al. (2019) studied Trypanosoma cruzi infection. TcUBP1 overexpression was evaluated on Expression of transcripts encoding surface proteins (>10 times up-regulated). Overexpression of TcUBP1 in Trypanosoma cruzi resulted in >10 times up-regulated expression of transcripts encoding surface proteins and increased their abundance in the polysome fraction.
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