Key result
TcUBP1 expression in T. cruzi drives infective differentiation and cuts mRNA translation ~8-fold.
The RNA-binding protein TcUBP1 acts as a translational repressor in Trypanosoma cruzi, promoting its differentiation from non-infective epimastigotes to infective metacyclic trypomastigotes.
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No immediate Chagas management implications; leaves open TcUBP1 targeting in future parasite and cardiomyopathy models.
Romaniuk et al. (2018) studied Trypanosoma cruzi. Ectopic inducible expression of TcUBP1 was evaluated on Differentiation to infective metacyclic trypomastigotes and translation rate. Ectopic expression of the RNA-binding protein TcUBP1 in Trypanosoma cruzi promoted differentiation into infective metacyclic trypomastigotes and reduced translation of a reporter mRNA by 8-fold.
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