Key result
Homograft aortic roots exhibited faster early calcification and lower freedom from reoperation at 8 years (93% vs 100%, P=0.01) compared to Medtronic freestyle roots.
Why the study?
Does homograft aortic root replacement compared to freestyle aortic root replacement affect the rate of calcification and clinical outcomes in patients undergoing total aortic root replacement?
Population
166 patients prospectively randomized to undergo total aortic root replacement
Comparison
Homograft total aortic root replacement vs Medtronic freestyle total aortic root replacement
Design
RCT, prospectively randomized
Follow-up
up to 8 years
Authors
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Supports freestyle over homograft roots to reduce reoperation; challenges homograft preference in aortic root replacement.
RCT (n=166)
Does homograft aortic root replacement compared to freestyle aortic root replacement affect the rate of calcification and clinical outcomes in patients undergoing total aortic root replacement?
p-value: p=0.02
Homograft aortic roots exhibit faster early calcification and higher rates of reoperation at 8 years compared to freestyle roots.
El-Hamamsy et al. (2009) conducted an RCT in Aortic root replacement (n=166). Homograft aortic root replacement vs. Medtronic freestyle aortic root replacement was evaluated on Degree and rate of calcification (calcium scores) (p=0.02). Homograft aortic roots exhibited faster early calcification and lower freedom from reoperation at 8 years (93% vs 100%, P=0.01) compared to Medtronic freestyle roots.
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