Key result
In grafted or denervated rat kidneys, responses to sympathomimetics shifted towards enhanced vasoconstriction and blunted vasodilatation, alongside deteriorated hemodynamic autoregulation.
Kidney transplantation and denervation in rats shift renal vascular responses to sympathomimetics towards enhanced vasoconstriction and blunted vasodilation, with deterioration of hemodynamic autoregulation.
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Enhanced vasoconstriction after rat kidney denervation warrants caution extrapolating to humans; leaves open clinical relevance for transplant autoregulation.
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Morita et al. (1999) studied Kidney transplantation and denervation. Kidney transplantation or denervation vs. Native kidney was evaluated on Renal blood flow (RBF) response to sympathomimetics (dopamine and phenylephrine). In grafted or denervated rat kidneys, responses to sympathomimetics shifted towards enhanced vasoconstriction and blunted vasodilatation, alongside deteriorated hemodynamic autoregulation.
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