Key result
Multiple-virus infections (33.1% of positive cases) were associated with significantly different clinical symptoms but similar disease severity compared to single-virus infections.
Why the study?
Data comparing single- and multiple-virus infections regarding the clinical manifestations of acute gastroenteritis were relatively limited.
Do multiple-virus infections alter clinical manifestations and disease severity compared to single-virus infections in children with acute gastroenteritis?
Cross-Sectional (n=2,383)
No
Do multiple-virus infections alter clinical manifestations and disease severity compared to single-virus infections in children with acute gastroenteritis?
Multiple-virus infections in pediatric acute gastroenteritis may present with different clinical symptoms but do not significantly increase disease severity compared to single-virus infections.
Multiple-virus infections may alter symptoms without increasing severity; hypothesis-generating, should not yet change practice.
Many different enteric viruses can cause acute gastroenteritis in humans worldwide. While a single virus can indeed cause disease, multiple-virus infections are commonly reported. However, data regarding a comparison between single- and multiple-virus infections upon clinical manifestations of acute gastroenteritis are relatively limited. In this study, a total of 2383 fecal specimens were collected from children with acute gastroenteritis during June 2014-July 2017 in a pediatric clinic in Japan and tested for 11 viruses by multiplex RT-PCR. At least 1 virus was found in 1706 (71.6%) specimens and norovirus GII was the most frequent agent, followed by rotavirus A and other viruses. Multiple-virus infections were identified in 565 cases (33.1%). While major clinical symptoms were found to be significantly different in some single- vs. multiple-virus infections, the disease severity was statistically non-significant. Our study highlights the burden of multiple-virus infections for acute gastroenteritis and the clinical features of patients with multiple-virus infections.
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Hikita et al. (2023) conducted a cross-sectional in Acute gastroenteritis (n=2,383). Multiple-virus infections vs. Single-virus infections was evaluated on Clinical manifestations and disease severity. Multiple-virus infections (33.1% of positive cases) were associated with significantly different clinical symptoms but similar disease severity compared to single-virus infections.
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