Key result
HIV-infected children with neutralizing antibody titers ≥ 225 experienced significantly fewer major clinical events during follow-up compared to those with lower titers (P = .0028).
Why the study?
Does the presence of HIV-1MN neutralizing antibody correlate with clinical status and predict clinical outcome in HIV-infected children?
Cohort (n=58)
Does the presence of HIV-1MN neutralizing antibody correlate with clinical status and predict clinical outcome in HIV-infected children?
p-value: p=.0028
Higher HIV-1MN neutralizing antibody titers (≥ 225) are associated with milder disease and fewer major clinical events in HIV-infected children.
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Supports prognostic role of titers; hypothesis-generating and should not change practice without prospective validation.
Guroff et al. (1993) conducted a cohort in HIV infection (n=58). Neutralizing antibody titers ≥ 225 vs. Neutralizing antibody titers < 225 was evaluated on Major clinical events during follow-up (p=.0028). HIV-infected children with neutralizing antibody titers ≥ 225 experienced significantly fewer major clinical events during follow-up compared to those with lower titers (P = .0028).
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