Key result
Multi-vessel coronary artery disease in patients presenting with acute myocardial infarction was associated with a significantly higher rate of in-hospital mortality (6% vs 2.5%, p<0.001) compared to non-multi-vessel disease.
Why the study?
Patients with multivessel coronary artery disease present with more comorbidities and poorer in-hospital outcomes than those with single-vessel disease, prompting an analysis of their clinical characteristics and short-term outcomes.
Does multi-vessel disease compared to single-vessel disease worsen in-hospital outcomes in patients presenting with acute myocardial infarction?
Observational (n=3,041)
No
Does multi-vessel disease compared to single-vessel disease worsen in-hospital outcomes in patients presenting with acute myocardial infarction?
Absolute Event Rate: 6% vs 2.5%
p-value: p=<0.001
Patients with AMI and multi-vessel disease have significantly higher rates of in-hospital mortality and LV dysfunction compared to those with single-vessel disease.
OBJECTIVE: Patients with multi-vessel coronary artery disease (MVD) compared to single-vessel coronary artery disease (CAD) have more comorbidities and poor in-hospital outcomes. We aim to analyze MVD-AMI patients regarding clinical data and short-term outcomes. METHODS: This is a retrospective analysis of the prospectively collected data registry, a single-center study reviewing the clinical details and hospital outcome measures of AMI patients referred to our center for early revascularization from 2016 to 2019. RESULT: Out of 3041 patients presented with AMI, 491 (16%) had MVD on coronary angiogram. MVD-AMI patients were older, had a higher prevalence of DM, HTN, and prior history of ischemic heart disease compared to the non- MVD -AMI group (p < 0.001 for all). However, they presented more with non-anterior myocardial infarction, showed higher rates of post-myocardial infarction LV dysfunction, and mortality (p < 0.001). Older MVD-AMI patients showed higher rates of in-hospital morbidities and mortality compared to younger ones (p < 0.001). MVD- AMI women and Middle Eastern patients were older and showed a higher prevalence of cardiovascular risk factors compared to MVD-AMI men and South Asian patient population respectively. There were no significant differences recorded among the different subgroups of MVD-AMI patients regarding the hospital outcome measures. CONCLUSION: Our study highlighted the clinical characters and poor outcomes of a high-risk group of MVD-AMI with different demographic backgrounds. Although age was a strong predictor for in-hospital poor outcomes, neither gender nor ethnicity affected the outcomes in them.
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Khaled et al. (2021) conducted an observational in Acute Myocardial Infarction (n=3,041). Multi-vessel coronary artery disease vs. Non-multi-vessel coronary artery disease was evaluated on In-hospital mortality (p=<0.001). Multi-vessel coronary artery disease in patients presenting with acute myocardial infarction was associated with a significantly higher rate of in-hospital mortality (6% vs 2.5%, p<0.001) compared to non-multi-vessel disease.
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