Key result
Periostin is expressed at the cellular level in healthy skin but localizes to the extracellular matrix during tissue remodeling, peaking at day 7 in murine excisional wounds.
Periostin functions as a matricellular protein that transitions from cellular to extracellular localization during dermal wound repair and pathological remodeling.
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Requires validation in human wounds before clinical consideration; extends knowledge of periostin transition during murine tissue repair.
Jackson‐Boeters et al. (2009) studied Wound repair (n=8). Excisional dermal wound vs. Unwounded skin was evaluated on Periostin expression and localization. Periostin is expressed at the cellular level in healthy skin but localizes to the extracellular matrix during tissue remodeling, peaking at day 7 in murine excisional wounds.
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