What question did this study set out to answer?

To review the physiological functions of the matricellular protein periostin in cutaneous maintenance and wound repair, alongside its pathological contributions to skin fibrosis and chronic inflammatory diseases.

January 1, 2014Allergology InternationalOpen Access

Periostin in Skin Tissue Skin-Related Diseases

Q: What is the clinical evidence from this study?

Study design: Review. Population: Skin-related diseases (Systemic sclerosis, Atopic dermatitis). Intervention: Periostin.

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Key result

Periostin plays a pivotal role in skin wound repair, fibrosis in systemic sclerosis, and chronic allergic inflammation in atopic dermatitis.

Design

Review

Authors

YYYukie YamaguchiYokohama City University

Discussion

Member takes

Implication

May support periostin targeting in atopic dermatitis and skin fibrosis; leaves open prospective clinical validation.

Key Points

To review the physiological functions of the matricellular protein periostin in cutaneous maintenance and wound repair, alongside its pathological contributions to skin fibrosis and chronic inflammatory diseases.
Phenotypic characterization of periostin-null mice to evaluate collagen fibrillogenesis, cross-linking, and extracellular matrix meshwork assembly.
Evaluation of disease severity in bleomycin-induced systemic sclerosis and house dust mite extract-induced atopic dermatitis mouse models lacking periostin, complemented by systemic sclerosis patient data.
Periostin is upregulated following mechanical stress or injury, accelerating wound closure by acting directly on fibroblasts and keratinocytes.
Periostin-null mice display attenuated dermal fibrosis in bleomycin-induced systemic sclerosis and reduced allergic inflammation in dust mite-induced atopic dermatitis.
Th2 cytokine-induced periostin triggers keratinocyte release of proinflammatory mediators, creating an amplification loop that sustains chronic skin inflammation.

PICO

Population

Skin-related diseases (Systemic sclerosis, Atopic dermatitis)

Exposure / Comparator

Periostin

Periostin is a key matricellular protein involved in the pathogenesis of skin fibrosis and atopic dermatitis, representing a potential therapeutic target for skin-related diseases.

Cite This Study

Yukie Yamaguchi (2014) conducted a review in Skin-related diseases (Systemic sclerosis, Atopic dermatitis). Periostin was evaluated. Periostin plays a pivotal role in skin wound repair, fibrosis in systemic sclerosis, and chronic allergic inflammation in atopic dermatitis.

synapsesocial.com/papers/6a9c9eaec6168cc7c6979705 https://doi.org/10.2332/allergolint.13-rai-0685

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Periostin in Skin Tissue Skin-Related Diseases

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Periostin in Skin Tissue Skin-Related Diseases

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

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