Key result
Glucose reduces fatty acid-induced release of lactate dehydrogenase from isolated coronary-ligated rat hearts, likely through the provision of glycolytic ATP from increased glycolytic flux.
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May protect ischemic rat myocardium via glycolytic ATP; leaves open translation to human coronary syndromes.
The mechanisms whereby glucose reduces fatty acid-induced release of enzyme from the coronary-ligated isolated perfused working rat heart are investigated. Alterations in the tissue contents of ATP, phosphocreatine, or glycogen could be excluded as possible mechanisms for the beneficial effect of glucose in this system. Provision of glycolytic ATP from increased glycolytic flux may be one important factor.
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OPIE et al. (1979) studied Coronary-ligated isolated perfused working rat heart. Glucose was evaluated on Fatty acid-induced release of lactate dehydrogenase. Glucose reduces fatty acid-induced release of lactate dehydrogenase from isolated coronary-ligated rat hearts, likely through the provision of glycolytic ATP from increased glycolytic flux.
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