Key result
The ky mutation depresses the normal post-natal transition towards faster muscles, resulting in adult muscles whose myosin isoforms are shifted in a fast-to-slow direction.
Authors
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May guide studies of muscle maturation; leaves open relevance to human myopathies or cardiac muscle.
Maréchal et al. (1996) studied Kyphoscoliosis. ky mutation vs. Normal pattern (wild-type/unaffected muscles) was evaluated on Myosin isoform maturation and expression. The ky mutation depresses the normal post-natal transition towards faster muscles, resulting in adult muscles whose myosin isoforms are shifted in a fast-to-slow direction.
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