Key result
Muscles from ky mice weighed <50% of controls, with adult ky soleus showing wholesale loss of intermediate-twitch native myosin and sole expression of slow-twitch native myosin 2.
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Ky mouse atrophy and slow myosin dominance are hypothesis-generating; leaves open relevance to human myopathies or remodeling.
Maréchal et al. (1995) studied kyphoscoliosis and muscle fiber necrosis. ky/ky mutation vs. age-matched NMRI mice was evaluated on Mechanical power and myosin composition. Muscles from ky mice weighed <50% of controls, with adult ky soleus showing wholesale loss of intermediate-twitch native myosin and sole expression of slow-twitch native myosin 2.
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