Population
Single muscle fibres from soleus and extensor digitorum longus muscles of genetically dystrophic mdx and…
Comparison
Chemical skinning with Triton X-100 and… vs Fibres from normal (C57BL/10) mice of similar age
Design
Preclinical
Authors
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Highlights fibre-specific contractile deficits in young mdx muscle; leaves open translation to human DMD or cardiac involvement.
Dystrophic mdx mice exhibit age- and muscle-specific alterations in contractile properties and myonuclear distribution, suggesting dystrophin-negative fibres can repair locally occurring muscle damage.
Williams et al. (1993) studied this question.
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