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September 17, 2019DiagnosticsOpen Access

Left Ventricular Diastolic Dysfunction in Type 2 Diabetes—Progress and Perspectives

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Key result

The updated 2016 algorithm for left ventricular diastolic dysfunction is more effective in predicting adverse cardiovascular events in established LVDD compared to 2009 recommendations.

Why the study?

Cardiovascular events are the leading cause of death in diabetic patients, requiring in-depth understanding of early cardiovascular manifestations such as left ventricular diastolic dysfunction.

Does the 2016 LVDD guideline algorithm improve the prediction of adverse cardiovascular events and grading of LVDD compared to the 2009 recommendations in patients with T2DM?

Comparison

2016 LVDD guidelines vs 2009 recommendations

Design

Review

Authors

EGElena-Daniela GrigorescuCLCristina-Mihaela LăcătușuMFMariana Floria

Discussion

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Member takes

Overview

May improve prognostication in established LVDD; leaves open prospective validation in T2DM amid higher indeterminate rates.

Structured PICO

Does the 2016 LVDD guideline algorithm improve the prediction of adverse cardiovascular events and grading of LVDD compared to the 2009 recommendations in patients with T2DM?

P
Population
Patients with type 2 diabetes mellitus (T2DM) undergoing echocardiographic assessment for left ventricular diastolic dysfunction (LVDD)
E
Exposure
Echocardiographic assessment using the 2016 LVDD guidelines
C
Comparator
Echocardiographic assessment using the 2009 LVDD recommendations
O
Outcome
Prediction of adverse cardiovascular events and grading of LVDDsurrogate

The 2016 LVDD guidelines improve prediction of adverse cardiovascular events in established LVDD but increase 'indeterminate' classifications, highlighting the need for further longitudinal studies in T2DM patients.

Limitations

  • The complex nature of T2DM calls for further research, specifically longitudinal studies on rigorously selected cohorts.
  • Complex nature of T2DM requires further research
  • Need for longitudinal studies on rigorously selected cohorts

Cite This Study

Grigorescu et al. (2019) conducted a review in Type 2 Diabetes Mellitus and Left Ventricular Diastolic Dysfunction. 2016 LVDD guidelines vs. 2009 LVDD recommendations was evaluated on Predicting adverse cardiovascular events. The updated 2016 algorithm for left ventricular diastolic dysfunction is more effective in predicting adverse cardiovascular events in established LVDD compared to 2009 recommendations.

synapsesocial.com/papers/6a9ca95d6a0b47dac776eb9dhttps://doi.org/10.3390/diagnostics9030121
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