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January 7, 2010AJP Regulatory Integrative and Comparative Physiology

Early effects of doxorubicin in perfused heart: transcriptional profiling reveals inhibition of cellular stress response genes

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Key result

Doxorubicin perfusion in rat hearts induced widespread transcriptional reprogramming, notably repressing numerous transcripts involved in cardiac stress response and stress signaling.

Population

Rat heart perfusion model

Design

Preclinical

Authors

MTMałgorzata Tokarska-SchlattnerInsermELEliana LucchinettiUniversity of AlbertaMZMichael ZauggUniversity of Alberta

Discussion

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Implication

Repressed stress responses may underlie doxorubicin cardiotoxicity; leaves open translation to human hearts.

Structured PICO

P
Population
Rat heart perfusion model used to determine the early cardiac transcriptional response to doxorubicin.
I
Intervention
Doxorubicin 2 muM perfusion
O
Outcome
Early cardiac transcriptional response measured by genome-wide transcriptome analysis (DNA microarrays)surrogate

Early doxorubicin exposure in a rat heart model blunts cellular stress responses and danger signaling, suggesting a mechanism for its cardiotoxic effects.

Cite This Study

Tokarska-Schlattner et al. (2010) studied Doxorubicin-induced cardiac toxicity. Doxorubicin (DXR) was evaluated on Cardiac transcriptional reprogramming. Doxorubicin perfusion in rat hearts induced widespread transcriptional reprogramming, notably repressing numerous transcripts involved in cardiac stress response and stress signaling.

synapsesocial.com/papers/6a9cab04c42eb00825f7bf07https://doi.org/10.1152/ajpregu.00360.2009
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  1. 1Probucol Protects Against Adriamycin Cardiomyopathy Without Interfering With Its Antitumor Effect1995 · 286 citations
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