Key result
Multivariate analysis of clinical risk factors improved risk assessment, identifying that 68.7% of pulmonary embolisms occurred in the 32.2% of the population designated as high risk.
Why the study?
Does multivariate analysis of clinical risk factors improve the assessment of risk for pulmonary embolism in hospitalized patients compared to lower extremity findings alone?
Cohort (n=6,527)
Does multivariate analysis of clinical risk factors improve the assessment of risk for pulmonary embolism in hospitalized patients compared to lower extremity findings alone?
Multivariate analysis of clinical factors significantly improves the identification of hospitalized patients at increased risk for pulmonary embolism compared to lower extremity findings alone.
May enhance PE risk stratification in hospitalized patients; leaves open effects on prophylaxis and outcomes.
A prospective study of 6,527 hospitalized patients was performed to evaluate the effectiveness of multivariate analysis of risk factors to correctly designate risk for pulmonary embolism. History of previous pulmonary embolism was the single most important factor. In patients without prior history, five factors emerged: inactivity, congestive heart failure, Doppler ultrasound evidence of deep-vein occlusion, female sex, and black race. Used together, these factors permitted a discrimination of risk such that 68.7% of pulmonary embolization was found to occur in 32.2% of the population designated as showing increased risk. Multivariate analysis of clinical factors improved assessment of risk, compared to the use of lower extremity findings alone, and proved to be useful in identifying individuals at increased risk for pulmonary embolism.
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Bernard Sigel (1979) conducted a cohort in Pulmonary embolism (n=6,527). Multivariate analysis of clinical risk factors vs. Lower extremity findings alone was evaluated on Risk of pulmonary embolism. Multivariate analysis of clinical risk factors improved risk assessment, identifying that 68.7% of pulmonary embolisms occurred in the 32.2% of the population designated as high risk.
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