Key result
Peripheral edema on admission in critically ill patients was associated with a 30% higher adjusted risk of developing acute kidney injury within the first 7 days (OR 1.30).
Why the study?
Does the presence of peripheral edema or elevated central venous pressure increase the risk of acute kidney injury in critically ill patients?
Cohort (n=12,778)
No
Does the presence of peripheral edema or elevated central venous pressure increase the risk of acute kidney injury in critically ill patients?
Odds Ratio: 1.3 (95% CI 1.15–1.46)
Absolute Event Rate: 27% vs 16.4%
p-value: p=<0.001
Venous congestion, indicated by peripheral edema or elevated central venous pressure, is independently associated with an increased risk of acute kidney injury in critically ill patients.
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Supports venous congestion assessment for AKI risk stratification in the ICU; leaves open causal implications and intervention effects.
Chen et al. (2016) conducted a cohort in Critical Illness / Acute Kidney Injury (n=12,778). Peripheral edema on admission vs. No peripheral edema was evaluated on Acute kidney injury (AKI) within the first 7 days of critical illness (OR 1.30, 95% CI 1.15 to 1.46, p=<0.001). Peripheral edema on admission in critically ill patients was associated with a 30% higher adjusted risk of developing acute kidney injury within the first 7 days (OR 1.30).
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