Key result
Among 37 British cases of primary hepatic angiosarcoma identified between 1963 and 1979, 4 were attributable to VCM exposure and 8 to intra-arterial Thorotrast.
Observational (n=37)
Yes
The British hepatic angiosarcoma register identified cases linked to VCM exposure and intra-arterial Thorotrast.
Answers are grounded in this paper and cite their sources.
Occupational exposure history review warranted in hepatic angiosarcoma; extends known VCM/Thorotrast links but leaves other etiologies open.
A register of British cases of primary hepatic angiosarcoma (HAS) was established in 1974 to monitor the occurrence of cases from 1963 onwards. Details of cases dying in 1963-77 have been obtained. Thirty-five cases were agreed as HAS by panel of liver pathologists, and occupational and medical information was obtained in the majority of these. Two cases were attributable to VCM exposure, and eight others had received intra-arterial Thorotrast. In 1978-79, two more cases were confirmed in VCM polymerization workers.
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Peter J. Baxter (1981) conducted an observational in Primary hepatic angiosarcoma (n=37). VCM exposure and Thorotrast was evaluated on Attribution to occupational and medical exposures. Among 37 British cases of primary hepatic angiosarcoma identified between 1963 and 1979, 4 were attributable to VCM exposure and 8 to intra-arterial Thorotrast.
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